Physical and chemical properties of 6-aminocaproic acid
2021-06-30 15:58:00 来源： 点击：
The chemical formula is H2NCH2(CH2)3CH2COOH. The molecular weight is 131.18. Obtain leaf crystals from ether. Odorless, bitter taste. The melting point is 202～207℃ (decomposition). It is soluble in water, slightly soluble in methanol, insoluble in ethanol, ether and chloroform. pK1=4.43, pK2=10.75. Oxidized with alkaline KMnO4 solution to generate adipic acid, 6-aminocaproic acid reacts with HNO2 to obtain 5-hexenoic acid and 4-hexenoic acid, boiled together with urea and barium hydroxide aqueous solution to generate 6-ureidohexanoic acid, Chemicalbook It reacts with ROH to form an ester, and reacts with RCOCl to introduce an acyl group on the amino group.
Preparation method: It is obtained by hydrolysis of 6-(N-benzamido)capronitrile in the presence of hydrochloric acid, or hydrolysis of caprolactam in the presence of hydrochloric acid, followed by treatment with ammonium hydroxide.
Uses: used in organic synthesis. As an anti-fibrinolytic enzyme reagent. Used as a hemostatic agent. It has obvious effect on some severe bleeding caused by increased fibrinolytic activity. It is suitable for bleeding or local bleeding during various surgical operations. It is also used for hemoptysis, gastrointestinal bleeding and obstetrics and gynecology hemorrhagic diseases.
